Review Article| Volume 56, ISSUE 1, P147-155, February 2023

Upper Airway Cough Syndrome

Published:October 22, 2022DOI:


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        • Song W.J.
        • Chang Y.S.
        • Faruqi S.
        • et al.
        The global epidemiology of chronic cough in adults: a systematic review and meta-analysis.
        Eur Respir J. 2015; 45: 1479-1481
        • Dąbrowska M.
        • Arcimowicz M.
        • Grabczak E.M.
        • et al.
        Chronic cough related to the upper airway cough syndrome: one entity but not always the same.
        Eur Arch Otorhinolaryngol. 2020; 277: 2753-2759
        • Pratter M.R.
        Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome): ACCP evidence-based clinical practice guidelines.
        Chest. 2006; 129: 63S-71S
        • Irwin R.S.
        • French C.L.
        • Chang A.B.
        • et al.
        CHEST Expert Cough Panel∗. Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report.
        Chest. 2018; 153: 196-209
        • Watelet J.B.
        • Van Zele T.
        • Brusselle G.
        Chronic cough in upper airway diseases.
        Respir Med. 2010; 104: 652-657
        • Sanu A.
        • Eccles R.
        Postnasal drip syndrome. Two hundred years of controversy between UK and USA.
        Rhinology. 2008; 86
        • Irwin R.S.
        • Curley F.S.
        • French F.L.
        Chronic cough: the spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.
        Am Rev Respir Dis. 1990; 141: 640-647
        • Pratter M.R.
        • Bartter T.
        • Lotano R.
        The role of sinus imaging in the treatment of chronic cough in adults.
        Chest. 1999; 116: 1287-1291
        • Lee J.H.
        • Lee J.W.
        • An J.
        • et al.
        Efficacy of non-sedating H1-receptor antihistamines in adults and adolescents with chronic cough: a systematic review.
        World Allergy Organ J. 2021; 14: 100568
        • Orlandi R.R.
        • Kingdom T.T.
        • Smith T.L.
        • et al.
        International consensus statement on allergy and rhinology: rhinosinusitis 2021.
        Int Forum Allergy Rhinol. 2021; 11: 213-739
        • Ciprandi G.
        • Buscaglia S.
        • Catrullo A.
        • et al.
        Loratadine in the treatment of cough associated with allergic rhinoconjunctivitis.
        Ann Allergy Asthma Immunol. 1995; 75: 115-120
        • Shioya T.
        • Satake M.
        • Kagaya M.
        • et al.
        Antitussive effects of the H1-receptor antagonist epinastine in patients with atopic cough (eosinophilic bronchitis).
        Arzneimittelforschung. 2004; 54: 207-212
        • Yu L.
        • Xu X.
        • Lv H.
        • et al.
        Advances in upper airway cough syndrome.
        Kaohsiung J Med Sci. 2015; 31: 223-228
        • Brozmanova M.
        • Bartos V.
        • Plank L.
        • et al.
        Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs.
        J Physiol Pharmacol. 2007; 58: 57-65
        • O'Hara J.
        • Jones N.S.
        "Post-nasal drip syndrome": most patients with purulent nasal secretions do not complain of chronic cough.
        Rhinology. 2006; 44: 270-273
        • Bardin P.G.
        • Van Heerden B.B.
        • Joubert J.R.
        Absence of pulmonary aspiration of sinus contents in patients with asthma and sinusitis.
        J Allergy Clin Immunol. 1990; 86: 82-88
        • Lucanska M.
        • Hajtman A.
        • Calkovsky V.
        • et al.
        Upper airway cough syndrome in pathogenesis of chronic cough.
        Physiol Res. 2020; 69: S35-S42
        • Kowalski M.L.
        • Dietrich-Miłobedzki A.
        • Majkowska-Wojciechowska B.
        • et al.
        Nasal reactivity to capsaicin in patients with seasonal allergic rhinitis during and after the pollen season.
        Allergy. 1999; 54: 804-810
        • O'Hanlon S.
        • Facer P.
        • Simpson K.D.
        • et al.
        Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.
        Laryngoscope. 2007; 117: 1519-1527
        • Niimi A.
        • Torrego A.
        • Nicholson A.G.
        • et al.
        Nature of airway inflammation and remodeling in chronic cough.
        J Allergy Clin Immunol. 2005; 116: 565-570
        • Hara J.
        • Fujimura M.
        • Ueda A.
        • et al.
        Effect of pressure stress applied to the airway on cough-reflex sensitivity in Guinea pigs.
        Am J Respir Crit Care Med. 2008; 177: 585-592
        • Yu L.
        • Xu X.
        • Wang L.
        • et al.
        Capsaicin-sensitive cough receptors in lower airway are responsible for cough hypersensitivity in patients with upper airway cough syndrome.
        Med Sci Monit. 2013; 19: 1095-1101
        • Bucca C.B.
        • Bugiani M.
        • Culla B.
        • et al.
        Chronic cough and irritable larynx.
        J Allergy Clin Immunol. 2011; 127: 412-419
        • Morice A.H.
        • Millqvist E.
        • Belvisi M.G.
        • et al.
        Expert opinion on the cough hypersensitivity syndrome in respiratory medicine.
        Eur Respir J. 2014; 44: 1132-1148
      1. Yasuda, K. Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study, Fam Pract, Volume 38, 6, December 2021, Pages 751–757.